Molecular Topology of RNA Polymerase I Upstream Activation Factor
نویسندگان
چکیده
منابع مشابه
RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.
Eukaryotic RNA polymerases are large complexes, 12 subunits of which are structurally or functionally homologous across the three polymerase classes. Each class has a set of specific subunits, likely targets of their cognate transcription factors. We have identified and characterized a human RNA polymerase I (Pol I)-specific subunit, previously identified as ASE-1 (antisense of ERCC1) and as CD...
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متن کاملThe RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein.
The accurate transcription of human rRNA genes by RNA polymerase I requires two transcription factors, upstream binding factor (UBF) and promoter selectivity factor (SL1). Human SL1 (hSL1) is a multisubunit complex, one of whose components is TATA box-binding protein (TBP). hSL1 binds to the core region of the rRNA promoter, but does so inefficiently in the absence of human UBF (hUBF). hUBF int...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2020
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00056-20